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Alzheimer's disease is a progressive brain disorder, in which the brain gradually degenerates. It most frequently occurs in people aged above 65 70 years. People with Alzheimer's disease develop distressing changes in memory, thought, function and behavior, which worsen over time. These changes increasingly impact upon the person's daily life, reducing their independence, until ultimately they are entirely dependent on others.

About Otsuka Pharmaceutical Co, Ltd.

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Taro Iwamoto, President and Representative Director of Otsuka Pharmaceutical Co., Ltd., noted with respect to Lu AE58054 "The global collaboration between Otsuka and Lundbeck continues to grow stronger with the addition of Lu AE58054. Not only does the product further enhance the synergy between the companies as we work together to bring to the market solutions for better health, Lu AE58054 is a potentially promising development in a very difficult disease area."

Alzheimer's disease also has an enormous impact on the patient's caregiver. Most caregivers are close relatives who provide care in the home a demanding and exhausting role that represents an emotional and physical burdenii.

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to lead the business, whose origins date from 1921.

and production facilities in Italy, France, Mexico, China and Denmark. Lundbeck generated revenue of approximately DKK 15 billion in 2012. Alzheimer's disease in real life the dementia carer's survey. Int J Geriatr Psychiatry 2008; 23 (5): 546 551.

Ulf Wiinberg, President Chief Executive Officer of Lundbeck commented "There is a serious, global, unmet medical need regarding treatments for Alzheimer's disease in aging populations. Together, Otsuka and Lundbeck with their development capabilities, commercial experience and geographical reach will provide a solid foundation in the development of Lu AE58054."

Under the terms of the agreement, Lundbeck will receive from Otsuka an initial payment of USD 150 million (approximately DKK 855 million) upon signing. Both companies will share the sales, development, and commercialization costs based on the agreement. Lundbeck is also entitled to up to USD 675 million (approximately DKK 3.9 billion) in regulatory and sales milestones. Additional specific financial terms of the agreement remain undisclosed.

Otsuka Pharmaceutical Co., Ltd. is a global healthcare company with the corporate philosophy: 'Otsuka people creating new products for better health worldwide.' Otsuka researches, develops, manufactures and markets innovative and original products, with a focus on pharmaceutical products for the treatment of diseases and nutraceutical products for the maintenance of everyday health. We are a "big venture" company at heart, applying a youthful spirit of creativity in everything we do. Tuberculosis, a global public health issue, is another research area that we have been active in for several decades. These commitments illustrate more powerfully than words how we are a "big venture" company at heart, applying a youthful spirit of creativity in everything we do.

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targeted at disorders such as depression and anxiety, psychotic disorders, epilepsy, Huntington's, Alzheimer's and Parkinson's diseases. Lundbeck's pipeline consists of several mid to late stage development programs.

H. For this purpose, Lundbeck is engaged in the entire value chain throughout research, development, production, marketing and sales of pharmaceuticals across the world. The company's products are Soccer Cleats Neymar 2016

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Otsuka is a wholly owned subsidiary of Otsuka Holdings Co., Ltd., the holding company for the Otsuka Group. Our chairman Akihiko Otsuka is the third generation of Otsuka family members Nike Football Shoes Mercurial Vapor Superfly

The pivotal clinical program with Lu AE58054 is planned to be initiated later in 2013. The global program will consist of several studies and include more than 2,500 patients. The first phase III study will enroll patients with mild to moderate Alzheimer's disease. Lu AE58054 will be tested as adjunct treatment to donepezil. Subsequent studies are expected to be initiated towards the end of 2013.

In May 2012, it was announced that Lu AE58054 had met its primary endpoint in a fixed dose, randomized, placebo controlled, 24 week clinical study in 278 patients. The study was conducted in patients suffering from moderate Alzheimer's disease, with Lu AE58054 administered as an add on to donepezil, a commonly used acetylcholinesterase inhibitori. The clinical data from the phase II study is planned to be presented at the annual Alzheimer's Association International Conference (AAIC) in Boston on 13 18 July 2013.

Worldwide, 36 million people have dementia. Perhaps as many as 28 million of the world's 36 million people with dementia have yet to receive a diagnosis and, therefore, do not have access to treatment, information and care. Every year, an estimated 4.6 million new cases are identifiediii. With the shift towards an increasingly elderly population, it is predicted that the number of people affected by dementia will almost double every 20 years, and by the year 2050, 115 million people will have the conditioniv.

Alzheimer's disease is the most common cause of dementia, accounting for 50 70% of casesv.

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iii Ferri CP, Prince M, Brayne C, et al. Nike Football Boots Purple And Orange Global prevalence of dementia: a Delphi consensus study. Lancet 2005; 366 (9503): 2112 2117.

Alzheimer's disease is associated with damages and death of brain cells, leading to significant brain shrinkage and neurotransmitter imbalances. As the brain cells degenerate, characteristic waste accumulates in the brain, known as 'plaques' and 'tangles'.

Lundbeck employs more than 5,800 people worldwide, 2,000 of whom are based in Denmark. We have employees in 57 countries, and our products are registered in more than 100 countries. We have research centers in Denmark, China and the United States Nike Football Boots Green And Orange

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´╗┐Otsuka Pharmaceutical Co Ltd and H Lundbeck A S Enter 825 Million Deal for Alzheimers Drug

The worldwide costs of dementia (USD 604 billion in 2010) amount to more than 1% of gross domestic product (GDP).

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TOKYO COPENHAGEN, Denmark (BUSINESS WIRE) H. Lundbeck A/S (Lundbeck) and Otsuka Pharmaceutical Co., Ltd. (Otsuka) today announced a license and development agreement for Lu AE58054, a selective 5HT6 receptor antagonist currently in development for the treatment of Alzheimer's disease.

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Nike Football Boots Purple And Orange

Nike Football Boots Purple And Orange

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